Clinical Trial Knowledge Center

Clinical Trials for Patients with Degenerative Disc Disease

Freedom® Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease
This study will look at the result of using the Freedom® Lumbar Disc (FLD) device as an artificial lumbar disc. Clinical trial participants with degenerative disc disease will be randomized to disc arthroplasty with the FLD device or a control device. The overall objective of this trial is to collect clinical data to demonstrate the safety and effectiveness of FLD used for the treatment of symptomatic lumbar degenerative disc disease compared to the control device.
To learn about this clinical trial click here.

Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease
The Activ-L™ Artificial Disc treatment study is open to subjects with single-level Degenerative Disc Disease (DDD) of the lumbar spine (L4/L5, or L5/S1), who are 18 to 60 years of age. This clinical investigation, sponsored by Aesculap Implant Systems, Inc., studies the safety and effectiveness of this new artificial disc in the treatment of lumbar DDD.
To learn about this clinical trial click here.

DIAM™ Spinal Stabilization System Clinical Trial
The purpose of this randomized study is to establish the safety and effectiveness of the DIAM™ Spinal Stabilization System in the treatment of moderate single-level lumbar degenerative disc disease. Patients enrolled in the study will be randomly assigned to receive either the investigational DIAM™ Device or non-surgical treatment that involves medication, physical therapy, patient education and spinal injections. Patients enrolled in the study must be evaluated by their surgeon at regular intervals.
To learn about this clinical trial, click here.

Clinical Trial for Patients with a Herniated Disc

DuraGen Plus® Adhesion Barrier Matrix
The DuraGen Plus® clinical trial is for patients who will undergo a spine operation because of a ruptured or slipped disc. Men and women between 18 and 70 years of age who meet the eligibility criteria may be candidates to participate in this controlled trial. This study will specifically evaluate the safety and effectiveness of an experimental product, called DuraGen Plus® Adhesion Barrier Matrix, which may help to minimize post-operative scarring and the pain that may result from that scarring.
To learn about this clinical trial click here.

Clinical Trial for Patients Suffering Scoliosis and Degenerative Disc Disease

Gene Mapping of Inherited Spinal Disorders (Scoliosis and Degenerative Disc Disease)
The identification of genetic markers linked to Scoliosis and Degenerative Disc Disease. By understanding the molecular causes for these conditions, Axial Biotech hopes to be able to develop diagnostic/prognostic tests and potentially improved treatment options. Individuals who will be considered for eligibility include: Men, women, and children who have a diagnosis of Scoliosis or Degenerative Disc Disease.
To learn more about this clinical trial click here.

Clinical Trials for Patients Suffering Spinal Stenosis

coflex^® Spine Study: Take a Stand Against Spinal Stenosis
The coflex medical device is in the new generation of dynamic stabilization implants designed to reduce nerve compression and create spinal stability while working to return the spine to a state that more closely resembles its normal physiology. A clinical research study is currently enrolling patients to determine the safety and effectiveness of the coflex dynamic stabilization implant as compared to pedicle screw fixation and spinal fusion.
To learn about this clinical trial click here, or contact the sponsor at coflexinfo@paradigmspine.com.

Facet Replacement System to Treat Spinal Stenosis
The purpose of this study is to determine if the ACADIA™ Facet Replacement System is effective in the treatment of lumbar spinal stenosis. The primary objective of the study is to evaluate the overall success rate of the ACADIA™ Facet Replacement System in patients with lumbar spinal stenosis when compared to a posterior spinal fusion control.
To learn about this clinical trial click here, or call 1-877-788-3925.

Superion^™ Interspinous Spacer in Lumbar Spinal Stenosis
The Superion^™ Interspinous Spacer is an investigational medical device designed to relieve chronic pain caused by moderate lumbar spinal stenosis and may offer a minimally invasive alternative to traditional spinal surgery. This may avoid the need for a large incision, and minimizing bleeding and trauma to the body.
To learn about this clinical trial click here.

Clinical Trial for Patients Suffering Vertebral Fracture

Crosstrees Medical Clinical Trial to Evaluate the Performance of the Crosstrees System in Reducing Pain and Decreasing the Risk of Cement Leakage in Vertebral Compression Fractures
The Crosstrees™ System uses a fabric Pod to control the delivery of bone cement to fractured vertebral bodies. This study is being performed to evaluate the Crosstrees System performance in reducing pain and decreasing the risk of cement leakage associated with vertebroplasty and kyphoplasty.
To learn more about this clinical trial, click here.

Cleveland Clinic: Research and Clinical Trials

Already a major center for spine related treatment and research, the Cleveland Clinic Spine Institute is developing unique technologies, new specialties and collaborative approaches for effectively managing back and neck disorders. Much of the research takes place within the Spine Research Laboratory, where studies in spinal biomechanics, pathogenesis of disc degeneration, microelectromechanical systems (MEMS), and nanotechnology are being conducted.
To learn more, click here.